Anticonvulsant effects?
Many Fatty acids have anticonvulsant properties and have been used to make anticonvulsant drugs. Does Omega 3 have the same properties? I suppose it could explain why it can help in depression, both unipolar and bipolar as a mood stabliiser?
IFOS inactive
The International Fish Oil Standards website has been inactive for some time now. Are there other independent fish oil testing services the article could list?
Ratio clarification
"Simopoulos, et al recommend daily intakes of three omega-3 forms: 650 mg of EPA and DHA , and 2.22 g of ALA, and one omega-6 form: 4.44 g of LA. This translates to a 3:2 omega-6 to omega-3 ratio. (i.e. 1.5:1)"
Is this to be taken at 650 mg of EPA in addition to 650 mg of DHA? (In addition to the 2.22 g of ALA and 4.44 g of LA)
Optimum Ratio?
any word on the optimum ratio of epa to dha? whether they are best taken together or separately?
Dangerous ratio listed
Sorry, I don't have your level of experience with Wiki editing and I don't even know if I'm allowed to do this, but the following may help editors so I'm jumping in. The following is important information to note in the article because the article suggests what could be a dangerous omega 6 (pro-inflammatory) to omega 3 ratio which is at odds with the following research.
References
1) ... Inflammation has a central role in the development and progression of coronary artery disease. Omega 3 fatty acids have recognised anti-inflammatory actions that may contribute to their beneficial cardiac effects. Omega 6 fatty acids can be converted into arachidonic acid and then metabolised into the omega 6 eicosanoids (fig 4). 20 These cellular mediators enhance platelet aggregation and are generally pro-inflammatory. Consumption of omega 3 fatty acids increases eicosapentanoic acid in the cell membrane. This competes with arachidonic acid for enzymatic conversion into its own metabolites, the omega 3 derived eicosanoids. These are less active and can partly oppose or antagonise the pro-inflammatory actions of the omega 6 eicosanoids. ...
... Independent of the effects on the metabolism of eicosanoids fish oils suppress pro-inflammatory cytokines and reduce expression of cell adhesion molecules. ...
http://www.bmj.com/cgi/content/full/328/7430/30
2) Diets With High Omega-6:Omega-3 Ratios Enhance Risk for Depression, Inflammatory Disease CME News Author: Marlene Busko Author: Hien T. Nghiem, MD April 26, 2007
http://www.medscape.com/viewarticle/555736
Summary
My understanding of the above research is ... if the Omega 3 fatty acid intake is increased it has a much greater chance of cancelling out the negative (pro-inflammatory) effect of the Omega 6s we consume - because 3 and 6 compete with each other for conversion.
Consumption of Omega 6 is typically very high in the western diet. This gives Omega 6s a competitive advantage and may be why Omega 6 has a free rein to cause inflammation, damage, and consequently pain. Therefore the purpose of increasing Omega 3 consumption is to dilute the Omega 6 advantage.
We need a balanced diet, including Omega 6, but by gaining a higher ratio of Omega 3s we improve their chances of cancelling out the pro-inflammatory effects of the Omega 6s.
Most research indicates fish oil supplementation is safe. The biggest safety issue appears to be capacity for blood thinning. This demands caution in terms of supplementation levels, especially if the diet's been modified to reduce cholesterol or the patient is on a medication that intentionally or unintentionally thins the blood.
The other safety issue (and the jury is still out on this one), is mercury contamination of the most popular source of Omega 3 supplementation, fish oil - so a reputable brand with exceptional quality process control should be the first choice.
Some research indicates 3g daily of Fish Oil may be the maximum upper safety level where there are no health or medical contraindications, with medical monitoring recommended above this level, however; medical monitoring is advisable for all when upper limits are being tested simply because the information available on upper limits is still not definitive.
Hope it helps,
Cris (casehealth.com.au)
Fish_high_in_omega-3.jpg
Do we really need this in the article?
File:Fish high in omega-3.jpg
It's basically just something someone should be able to read as text within the article, but not view as a picture. I'm removing it.
Cleanup strategy
This article is definitely a mess. At this point the optimal organization of the article is unclear to me, though we can definitely do without these massive lists. For sources, I say we should stick to journal-published "overview"-type articles, like this 2002 American Heart Association statement. (A newer one would be good too, if one exists.) A single study does not a proof make.
This article is now a terrible mess. It has problems with NPOV, writing style, formatting, and an immense number of references at the end which are not referenced in the text. Major cleanup work is needed. -- Karada 23:57, 3 August 2005 (UTC)
As the article stands, many of the various links and citations go to sites which have vested interests in the health-food industry. I think the best approach right now is to go through and do a plain fact-check. - mak o 23:24, 6 August 2005 (UTC)
I agree, it needs an organizational structure before any cleanup can take place. A good structure informs the editorial process. The St Johns Wort article is good in both it's brevity and objectivity. Here's a possible structure based on that:
- What is Omega 3 What are EFAs, chemical structure, where does it come from (fish, flax, etc.).
- How people are using it Covering both historical (fish?) and modern uses. This is where some of the spurious claims can be made. This and the preceding section form a good overview and set up the rest of the article as supporting evidence and practical information.
- Clinical Evidence Both for & against. Focus on legitimate studies rather than anecdotal evidence.
- Pharmacology what it does in the body. This section could, perhaps, be moved up or incorporated into the earlier sections.
- Dose/Formulations This and the next two sections are all the stuff you need to know if you want to take it. This might be a good place to talk about the Omega 3/Omega 6 balance.
- Adverse effects
- Drug interactions
- References
- See Also Fatty Acids, EFAs, Omega 6, etc.
- External Links
(01:19, 7 August 2005 MarkTAW)
That's a good framework to start with, thanks. - mak o 02:17, 9 August 2005 (UTC)
Found this database that has fairly objective information on vitamins, herbs, etc. It rates the validity of all of it's claims based on the number of studies that have been done. http://www.gnc.com/health_notes/healthnotes.aspx?ContentId=2843005&lang=en (Disclaimer: My girlfriend works for GNC) (MarkTAW 7:19, August 9, 2005)
This article need much work to improve it, I also believe that footnotes at the bottom, is better than to links. If no one has a problem, I will change webarticles with actual researchs. I'm planning to creat a section with the different conditions which are treated with Omega 3, and the relevant research, with graphics etc. Fadix 02:13, 21 October 2005 (UTC)
I just went through this article and turned all the periodical citations in running into ref-note labels and did a bunch of other light copy editing and organizing. It might not be good yet, but it's less of a chaotic mess. jengod 20:51, 3 January 2006 (UTC)
As of 22 Feb 06, the article seems much cleaner at the top (definition and chemistry) and bottom (sources), but still a mess in the middle (benefits/risks). I would suggest that those more competent in pharmacology and medicine clean up the benefits and risks section, firstly by segregating "known" from "suspected" from "possible". Perhaps a section below the Chemistry subsection which describes the metabolic pathway. Its looking a lot cleaner now! Istvan 16:58, 23 February 2006 (UTC)
Ending the NPOV dispute
{{npov}} has now been on this page for eight months . This is completely unacceptable. Please remember that {{npov}} is not something you just slap on a page and move on; you must join in trying to resolve the POV dispute. From this talk page, I can't see that there is any progress towards consensus-reaching going on. Will those of you who think this article violates NPOV please list your concerns here? Please do not dispute those concerns here yet (though feel free to edit the article to address them)—I just want to try to get everything aired out so we can get the NPOV tag removed. (I have no vested interest in this dispute, having never contributed to this article; I just want to see the POV dispute finished.) --TreyHarris 21:11, 28 January 2006 (UTC)
Having garnered no response, I am removing the NPOV tag. If someone wishes to restore it, please state your specific objections to the neutrality of the article here. --TreyHarris 09:14, 2 February 2006 (UTC)
Proof versus indication
This article uses 'prove' (or derivatives) an awful lot. That can't be right.
I suggest t
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